PARTIAL SYNTHESIS OF ETIOCHOLENE-9-OL-3(α)-ONE-17

Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol

Endogenous pregnane neurosteroids are allosteric modulators at γ-aminobutyric acid type-A (GABAA) receptors at nanomolar concentrations. There is direct evidence for multiple distinct neurosteroid binding sites on GABAA receptors, dependent upon subunit composition and stoichiometry. This view is supported by the biphasic kinetics of various neuroactive steroids, enantioselectivity of some neur...

9-Allyl-9H-fluoren-9-ol

The asymmetric unit of the title compound, C16H14O, contains two independent mol-ecules differing in the orientations of the allyl groups; the corresponding O-C-C(H2)-C(H) torsion angles are -61.01 (13) and -177.43 (10)°. In the crystal, O-H⋯O hydrogen bonds link four mol-ecules into a centrosymmetric tetra-mer, in which each hy-droxy group acts as a donor and an acceptor of hydrogen bonds.

Isolation of i-androstan-6-ol-17-one from urine of patients with adrenal neoplasm.

17α-Ethynyl-3-methoxy­estra-1,3,5(10),9(11)-tetraen-17-ol

In the title compound, C(21)H(24)O(2), rings B, C and D adopt half-chair, distorted half-chair and envelope conformations, respectively. In the crystal structure, there is an inter-molecular O-H⋯O hydrogen bond. The mol-ecules are arranged in a head-to-tail fashion, with the meth-oxy and hydr-oxy groups forming a two-dimensional hydrogen-bond network.

(Z)-3α-(1,3-Dioxoisoindolin-2-yl)-17(20)-pregnene

The title compound, C(29)H(37)NO(2), crystallized with two independent mol-ecules in an asymmetric unit in which the conformation of the cyclo-hexyl ring of the pregnene moiety bonded to the 3α-(1,3-dioxoisoindolin-2-yl)- ring system differs: in one mol-ecule it is in a chair conformation, while in the other it exhibits a half-chair conformation. The other six-membered rings in the pregnene moi...